If not clear already backpack comparisons are usually on stated base weight i.e pack weight less food, consumables and water; they change and are used up. Believe it or not I do have twig toothbrushes and a deodorant crystal.
As ever on weight discussions it depends; for a few days walk I guess weight hardly matters. Taking on a multi month hike that some of us have undertaken one hardly sees a heavy pack; and if you do, although happy, people with them are walking short distances-8-10 miles a day-because of the time spent on rests.
Three days from the southern start of the Appalachian Trail at the Neels Gap Outfitters each year they send tons, yes tons, of heavy unwanted gear back home to people as they buy lighter gear. After three days walking people have seen what other people are carrying and have discussed gear a lot and reduce base weight. Also a lot quit there as the trail is not what they thought it would be.
Opinions on here are anecdotal, including mine, but there are studies by the Arthritis society, the US Military and US Universities on the incremental trauma on the body of weight, also on weight and the energy cost of carrying or running with backpack.
Yes you can carry it but there is energy and possibly a body price to pay and if the calories are not replaced effectively on long trips you have to quit as fatigue and injuries occur. Replacing calories in a wilderness means carrying more food which is- err heavy.